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Stem Cell or Surgery?

Stem Cell Therapy -The Smart Alternative to Surgery? -Yes, Here’s Why. Stem cell therapy is an emerging intervention in the field of regenerative medicine. It

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White Papers

Wharton’s Jelly The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells. (MSC)

Abstract
The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the increased activity, several aspects of this cell population have been under-appreciated.

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Umbilical Cord Tissue for Research and Clinical Application
Abstract
Variations in allogeneic mesenchymal stem cell harvest levels from human tissues reflect the evolving nature of the field, patient demographic characteristics, and differences
in harvest and isolation techniques. At present,Wharton’s jelly tissue yields the highest concentration of allogeneic mesenchymal stem cells

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Effect of Aging on Stem Cells
Abstract
Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered.

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Consequences of Telomere Shortening During Lifespan
Abstract
Telomerase expression is restricted in human cells and so telomeres shorten throughout our lives, providing a tumor suppressor mechanism that limits cell proliferation. As a trade-off, continuous telomere erosion results in replicative senescence and contributes to aging.

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Minimal criteria for defining multipotent mesenchymal stromal cells.
Abstract
The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of biomedical disciplines. However, investigators report studies of MSC using different methods of isolation and expansion, and different approaches to characterizing the cells. Thus it is increasingly difficult to compare and contrast study outcomes, which hinders progress in the field.

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Mesenchymal Stem Cells: Mechanisms of Inflammation
Abstract
In adults, human mesenchymal stem cells (hMSCs) are found in vivo at low frequency and are defined by their capacity to differentiate into bone, cartilage, and adipose tissue, depending on the stimuli and culture conditions under which they are expanded. Although MSCs were initially hypothesized to be the panacea for regenerating tissues,MSCs appear to be more important in therapeutics to regulate the immune response invoked in settings such as tissue injury, transplantation, and autoimmunity.

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Applications of AmnioticMembrane and Fluid in Stem Cell Biology and Regenerative Medicine
Abstract
The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the increased activity, several aspects of this cell population have been under-appreciated.

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Don’t Just Take Our Word For It…

View Published Research on the Safety and Effectiveness of Stem Cell Therapy

 

Mesenchymal Stem Cells (MSC) have the potential to regenerate cartilage. Studies have shown the Mesenchymal Stems Cells can improve joint function and reduce pain with no adverse events

 

Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy.

Ding DC, Chang YH, Shyu WC, Lin SZ.

Cell Transplant. 2015;24(3):339-47. doi: 10.3727/096368915X686841. Epub 2015 Jan 23. Review.

PMID: 25622293

Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial.

Wang Y, Shimmin A, Ghosh P, Marks P, Linklater J, Connell D, Hall S, Skerrett D, Itescu S, Cicuttini FM.

Arthritis Res Ther. 2017 Aug 2;19(1):180. doi: 10.1186/s13075-017-1391-0.

PMID: 28768528

Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.

Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS.

Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634. Erratum in: Stem Cells. 2017 Jun;35(6):1651-1652.

PMID: 24449146

Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A 2-Year Follow-up Study.

Jo CH, Chai JW, Jeong EC, Oh S, Shin JS, Shim H, Yoon KS.

Am J Sports Med. 2017 Jul 1:363546517716641. doi: 10.1177/0363546517716641. [Epub ahead of print]

PMID: 28746812

Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel: Results from a Clinical Trial for Safety and Proof-of-Concept with 7 Years of Extended Follow-Up.

Park YB, Ha CW, Lee CH, Yoon YC, Park YG.

Stem Cells Transl Med. 2017 Feb;6(2):613-621. doi: 10.5966/sctm.2016-0157. Epub 2016 Sep 9.

PMID: 28191757

Mesenchymal stem cells in synovial fluid increase after meniscus injury.

Matsukura Y, Muneta T, Tsuji K, Koga H, Sekiya I.

Clin Orthop Relat Res. 2014 May;472(5):1357-64. doi: 10.1007/s11999-013-3418-4. Epub 2013 Dec 13. Erratum in: Clin Orthop Relat Res. 2014 Mar;472(3):1049.

PMID: 24338094

Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial.

Saw KY, Anz A, Siew-Yoke Jee C, Merican S, Ching-Soong Ng R, Roohi SA, Ragavanaidu K.

Arthroscopy. 2013 Apr;29(4):684-94. doi: 10.1016/j.arthro.2012.12.008. Epub 2013 Feb 4.

PMID: 23380230

Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D.

Pain Physician. 2008 May-Jun;11(3):343-53.

PMID: 18523506

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Before you consider surgery, call our office to see if you may qualify for regenerative cell therapy.  Our dedicated & compassionate team of practitioners are here to help you get real results and the quality of life you deserve.

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Summit Health Centers is an innovative industry leader providing the highest quality level of services all while being grounded in the core principles of Integrity, Determination, and Committment.

Summit Health Centers and affiliates do not claim that treatment using stem cells are a cure for any condition, disease, or injury. Regenerative cell therapy (Often referred to as “Stem cell therapy”) is not a part of FDA approved stem cell therapies and is not considered a cure for any medical condition. All statements and opinions provided on this website are for educational and informational purposes only and we do not diagnose or give medical advise via this website.

Individuals interested in regenerative cell therapy are urged to review all pertinent information and do their own research before choosing to participate in regenerative cell therapy. Please note, there is no guarantee of specific results with our care and results may vary. Please contact us to discuss your specific condition. Per FTC GUIDE LINES CONCERNING USE OF ENDORSEMENTS AND TESTIMONIALS IN ADVERTISING, PLEASE BE AWARE OF THE FOLLOWING: Federal regulation requires us to inform our customers that all product reviews, testimonials or endorsements of products sold & services received through our office reflects the personal experience of those individuals. They are expressing their personal opinions on our products and services and that those opinions and experiences may not be representative of what every consumer of our products may personally experience with the endorsed product.

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